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On 1 June, 2019, in one of the biggest upsets in boxing history, 25–1 underdog Andy Ruiz Jr. walked into Madison Square Garden and knocked undefeated heavyweight champion Anthony Joshua off his feet. Several times.
The reigning champion managed to get back to his feet after each time, but after the last knock down, Joshua was clearly disoriented and unable to convincingly show that he was ok to go on. Referee Michael Griffin, having seen enough of the damage done, waved off the fight, handing Joshua his first loss in 24 fights.